Which statement most accurately describes Acute cholecystitis?

A. A full-thickness breach of bowel that may release contents into the peritoneal cavity. B. Partial or complete separation of a surgical wound after closure. C. Mechanical or functional blockage causing pain, vomiting, distension and reduced passage of stool or flatus. D. Inflammation of the gallbladder, commonly due to cystic-duct obstruction by a stone.