CPSP FCPS I Medicine Allied MCQs

Apoptosis is programmed cell death with cell shrinkage and minimal inflammation.

Reed-Sternberg cell is a large atypical cell classically associated with Hodgkin lymphoma.

Agonist is a ligand that binds to a receptor and activates it to produce a biological response.

Competitive antagonist is a reversible receptor blocker whose effect can be overcome by increasing agonist concentration.

First-pass metabolism is presystemic metabolism that reduces oral bioavailability before a drug reaches systemic circulation.

Half-life is the time required for the plasma concentration of a drug to fall by one half.

Therapeutic index is a measure comparing toxic and effective doses and indicating a drug safety margin.

Loading dose is an initial larger dose used to achieve a target concentration rapidly.

Coagulative necrosis is a pattern of cell death with preserved tissue architecture, typical of ischaemia in solid organs except brain.

Coagulative necrosis is a pattern of cell death with preserved tissue architecture, typical of ischaemia in solid organs except brain.

Caseous necrosis is a friable cheese-like pattern of necrosis classically associated with tuberculosis.

Granuloma is an organised collection of activated macrophages formed in response to persistent inflammation.