MCQ Collection
Medical Comprehensive Ability MCQs
Practice Medical Comprehensive Ability questions with answers and explanations.
Choose an option to check your answer.
A.
The kidneys cannot affect acid-base balance
B.
Compensation changes the other component of the bicarbonate-carbon dioxide system but does not remove the primary disorder
C.
The lungs regulate bicarbonate directly as their main action
D.
Compensation always overshoots to the opposite pH disorder
Show Answer
Correct Answer: B. Compensation changes the other component of the bicarbonate-carbon dioxide system but does not remove the primary disorder
Explanation:
Respiratory and renal responses limit pH change while the primary process remains identifiable.
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A.
Inflammation occurs without signalling molecules
B.
Acute inflammation never recruits leukocytes
C.
All mediators have identical effects
D.
Inflammatory mediators coordinate vascular change, leukocyte recruitment and local symptoms
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Correct Answer: D. Inflammatory mediators coordinate vascular change, leukocyte recruitment and local symptoms
Explanation:
Multiple mediators act on vessels, cells and tissues to produce the organised inflammatory response.
Choose an option to check your answer.
A.
Acute inflammation never recruits leukocytes
B.
Inflammatory mediators coordinate vascular change, leukocyte recruitment and local symptoms
C.
All mediators have identical effects
D.
Inflammation occurs without signalling molecules
Show Answer
Correct Answer: B. Inflammatory mediators coordinate vascular change, leukocyte recruitment and local symptoms
Explanation:
Multiple mediators act on vessels, cells and tissues to produce the organised inflammatory response.
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A.
Tumours are unrelated to selection among cell clones
B.
A single mutation always produces invasive cancer immediately
C.
DNA repair has no relevance to cancer risk
D.
Cancer develops through accumulated alterations affecting growth control, survival, repair and the tissue environment
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Correct Answer: D. Cancer develops through accumulated alterations affecting growth control, survival, repair and the tissue environment
Explanation:
Tumorigenesis is multistep and reflects genetic, epigenetic and microenvironmental selection.
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A.
Clearance has no relationship to elimination
B.
Maintenance dosing depends only on tablet colour
C.
Clearance relates elimination rate to drug concentration and helps determine maintenance dosing
D.
Clearance is the same as absorption fraction
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Correct Answer: C. Clearance relates elimination rate to drug concentration and helps determine maintenance dosing
Explanation:
Systemic clearance describes the effective volume cleared per unit time and links concentration to elimination rate.
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A.
Antibiotics deliberately teach each bacterium to resist
B.
Antibiotic exposure can select resistant organisms already carrying or acquiring resistance determinants
C.
Resistance has no genetic basis
D.
Stopping all infection control prevents resistance
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Correct Answer: B. Antibiotic exposure can select resistant organisms already carrying or acquiring resistance determinants
Explanation:
Selection favours resistant variants, while transmission and gene exchange can spread resistance.
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A.
Specific lymphocytes activate without any signal
B.
Co-stimulation is irrelevant to immune tolerance
C.
Antigen recognition plus appropriate co-stimulation and cytokine signals shape lymphocyte activation and differentiation
D.
Cytokines cannot influence cell differentiation
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Correct Answer: C. Antigen recognition plus appropriate co-stimulation and cytokine signals shape lymphocyte activation and differentiation
Explanation:
Adaptive responses integrate receptor specificity with co-stimulatory and environmental signals.
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A.
Measurement methods cannot introduce systematic error
B.
Bias is a systematic error in selection, measurement or analysis that can distort an estimated association
C.
Random error and bias are identical
D.
Bias is eliminated automatically by a large sample
Show Answer
Correct Answer: B. Bias is a systematic error in selection, measurement or analysis that can distort an estimated association
Explanation:
Larger samples reduce random error but do not necessarily correct systematic design or measurement problems.
Choose an option to check your answer.
A.
Transport proteins cannot be selective
B.
All membrane transport directly hydrolyses ATP
C.
Net passive transport follows an electrochemical gradient and does not directly consume ATP
D.
Diffusion moves every solute against its gradient
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Correct Answer: C. Net passive transport follows an electrochemical gradient and does not directly consume ATP
Explanation:
Passive transport is driven by concentration and electrical gradients, although channels or carriers may facilitate it.
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A.
Afterload can never influence ejection
B.
Cardiac output equals heart rate multiplied by stroke volume and changes with preload, contractility and afterload
C.
Stroke volume is unrelated to venous return
D.
Cardiac output equals blood pressure divided by temperature
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Correct Answer: B. Cardiac output equals heart rate multiplied by stroke volume and changes with preload, contractility and afterload
Explanation:
Cardiac output integrates rate and stroke volume, while loading conditions and contractility influence stroke volume.
Choose an option to check your answer.
A.
Compensation always overshoots to the opposite pH disorder
B.
The kidneys cannot affect acid-base balance
C.
The lungs regulate bicarbonate directly as their main action
D.
Compensation changes the other component of the bicarbonate-carbon dioxide system but does not remove the primary disorder
Show Answer
Correct Answer: D. Compensation changes the other component of the bicarbonate-carbon dioxide system but does not remove the primary disorder
Explanation:
Respiratory and renal responses limit pH change while the primary process remains identifiable.
Choose an option to check your answer.
A.
A reversible competitive antagonist shifts an agonist concentration-response curve to the right without reducing maximal response when enough agonist is available
B.
A reversible competitive antagonist necessarily lowers the maximal response even when much higher agonist concentrations are available
C.
A competitive antagonist increases agonist potency by shifting the concentration-response curve left while leaving receptor occupancy unchanged
D.
An irreversible antagonist permanently occupies receptors, so increasing agonist concentration fully restores the original maximal response
Show Answer
Correct Answer: A. A reversible competitive antagonist shifts an agonist concentration-response curve to the right without reducing maximal response when enough agonist is available
Explanation:
Competition at the same receptor can be overcome by higher agonist concentration, reducing apparent potency but not efficacy.
