MCQ Collection
Medical Comprehensive Ability MCQs
Practice Medical Comprehensive Ability questions with answers and explanations.
Choose an option to check your answer.
A.
All membrane transport directly hydrolyses ATP
B.
Net passive transport follows an electrochemical gradient and does not directly consume ATP
C.
Transport proteins cannot be selective
D.
Diffusion moves every solute against its gradient
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Correct Answer: B. Net passive transport follows an electrochemical gradient and does not directly consume ATP
Explanation:
Passive transport is driven by concentration and electrical gradients, although channels or carriers may facilitate it.
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A.
Cardiac output equals blood pressure divided by temperature
B.
Stroke volume is unrelated to venous return
C.
Cardiac output equals heart rate multiplied by stroke volume and changes with preload, contractility and afterload
D.
Afterload can never influence ejection
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Correct Answer: C. Cardiac output equals heart rate multiplied by stroke volume and changes with preload, contractility and afterload
Explanation:
Cardiac output integrates rate and stroke volume, while loading conditions and contractility influence stroke volume.
Choose an option to check your answer.
A.
The kidneys cannot affect acid-base balance
B.
Compensation always overshoots to the opposite pH disorder
C.
The lungs regulate bicarbonate directly as their main action
D.
Compensation changes the other component of the bicarbonate-carbon dioxide system but does not remove the primary disorder
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Correct Answer: D. Compensation changes the other component of the bicarbonate-carbon dioxide system but does not remove the primary disorder
Explanation:
Respiratory and renal responses limit pH change while the primary process remains identifiable.
Choose an option to check your answer.
A.
All mediators have identical effects
B.
Inflammatory mediators coordinate vascular change, leukocyte recruitment and local symptoms
C.
Inflammation occurs without signalling molecules
D.
Acute inflammation never recruits leukocytes
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Correct Answer: B. Inflammatory mediators coordinate vascular change, leukocyte recruitment and local symptoms
Explanation:
Multiple mediators act on vessels, cells and tissues to produce the organised inflammatory response.
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A.
Tumours are unrelated to selection among cell clones
B.
A single mutation always produces invasive cancer immediately
C.
Cancer develops through accumulated alterations affecting growth control, survival, repair and the tissue environment
D.
DNA repair has no relevance to cancer risk
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Correct Answer: C. Cancer develops through accumulated alterations affecting growth control, survival, repair and the tissue environment
Explanation:
Tumorigenesis is multistep and reflects genetic, epigenetic and microenvironmental selection.
Choose an option to check your answer.
A.
Clearance has no relationship to elimination
B.
Maintenance dosing depends only on tablet colour
C.
Clearance is the same as absorption fraction
D.
Clearance relates elimination rate to drug concentration and helps determine maintenance dosing
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Correct Answer: D. Clearance relates elimination rate to drug concentration and helps determine maintenance dosing
Explanation:
Systemic clearance describes the effective volume cleared per unit time and links concentration to elimination rate.
Choose an option to check your answer.
A.
A reversible competitive antagonist necessarily lowers the maximal response even when much higher agonist concentrations are available
B.
A reversible competitive antagonist shifts an agonist concentration-response curve to the right without reducing maximal response when enough agonist is available
C.
A competitive antagonist increases agonist potency by shifting the concentration-response curve left while leaving receptor occupancy unchanged
D.
An irreversible antagonist permanently occupies receptors, so increasing agonist concentration fully restores the original maximal response
Show Answer
Correct Answer: B. A reversible competitive antagonist shifts an agonist concentration-response curve to the right without reducing maximal response when enough agonist is available
Explanation:
Competition at the same receptor can be overcome by higher agonist concentration, reducing apparent potency but not efficacy.
Choose an option to check your answer.
A.
Antibiotic exposure can select resistant organisms already carrying or acquiring resistance determinants
B.
Stopping all infection control prevents resistance
C.
Antibiotics deliberately teach each bacterium to resist
D.
Resistance has no genetic basis
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Correct Answer: A. Antibiotic exposure can select resistant organisms already carrying or acquiring resistance determinants
Explanation:
Selection favours resistant variants, while transmission and gene exchange can spread resistance.
Choose an option to check your answer.
A.
Co-stimulation is irrelevant to immune tolerance
B.
Antigen recognition plus appropriate co-stimulation and cytokine signals shape lymphocyte activation and differentiation
C.
Specific lymphocytes activate without any signal
D.
Cytokines cannot influence cell differentiation
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Correct Answer: B. Antigen recognition plus appropriate co-stimulation and cytokine signals shape lymphocyte activation and differentiation
Explanation:
Adaptive responses integrate receptor specificity with co-stimulatory and environmental signals.
Choose an option to check your answer.
A.
Clearance has no relationship to elimination
B.
Clearance is the same as absorption fraction
C.
Clearance relates elimination rate to drug concentration and helps determine maintenance dosing
D.
Maintenance dosing depends only on tablet colour
Show Answer
Correct Answer: C. Clearance relates elimination rate to drug concentration and helps determine maintenance dosing
Explanation:
Systemic clearance describes the effective volume cleared per unit time and links concentration to elimination rate.
Choose an option to check your answer.
A.
A reversible competitive antagonist necessarily lowers the maximal response even when much higher agonist concentrations are available
B.
An irreversible antagonist permanently occupies receptors, so increasing agonist concentration fully restores the original maximal response
C.
A reversible competitive antagonist shifts an agonist concentration-response curve to the right without reducing maximal response when enough agonist is available
D.
A competitive antagonist increases agonist potency by shifting the concentration-response curve left while leaving receptor occupancy unchanged
Show Answer
Correct Answer: C. A reversible competitive antagonist shifts an agonist concentration-response curve to the right without reducing maximal response when enough agonist is available
Explanation:
Competition at the same receptor can be overcome by higher agonist concentration, reducing apparent potency but not efficacy.
Choose an option to check your answer.
A.
All mediators have identical effects
B.
Acute inflammation never recruits leukocytes
C.
Inflammatory mediators coordinate vascular change, leukocyte recruitment and local symptoms
D.
Inflammation occurs without signalling molecules
Show Answer
Correct Answer: C. Inflammatory mediators coordinate vascular change, leukocyte recruitment and local symptoms
Explanation:
Multiple mediators act on vessels, cells and tissues to produce the organised inflammatory response.
