Practice CPSP FCPS I Anaesthesiology questions with answers and explanations.
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First-pass metabolism is presystemic metabolism that reduces oral bioavailability before a drug reaches systemic circulation.
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Half-life is the time required for the plasma concentration of a drug to fall by one half.
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Therapeutic index is a measure comparing toxic and effective doses and indicating a drug safety margin.
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Loading dose is an initial larger dose used to achieve a target concentration rapidly.
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ACE inhibitor is a drug class that reduces angiotensin II formation and may cause cough or hyperkalaemia.
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Beta blocker is a drug class that antagonises beta-adrenergic receptors and can reduce heart rate.
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Proton-pump inhibitor is a drug that irreversibly suppresses the gastric hydrogen-potassium ATPase.
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Naloxone is a competitive opioid receptor antagonist used to reverse opioid toxicity.
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Atropine is a muscarinic receptor antagonist that can increase heart rate and reduce secretions.
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Gastrin is a gastrointestinal hormone that stimulates gastric acid secretion and mucosal growth.
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Erythropoietin is a renal hormone that stimulates red-cell production in bone marrow during hypoxia.
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Ovulation is release of a mature oocyte from the dominant follicle after the mid-cycle luteinising hormone surge.
