Which statement most accurately describes Acute coronary syndrome?

A. Hyperglycaemia with ketonaemia and metabolic acidosis due to severe insulin deficiency. B. Obstruction of pulmonary arteries, commonly by thrombus originating in deep veins. C. Heavy proteinuria with hypoalbuminaemia, oedema and often hyperlipidaemia. D. A clinical spectrum caused by acute myocardial ischaemia, including unstable angina and myocardial infarction.