Which statement most accurately describes Cirrhosis?

A. A macrocytic anaemia caused by impaired DNA synthesis, often from folate or vitamin B12 deficiency. B. A state of deficient thyroid hormone action that may cause fatigue, weight gain and bradycardia. C. Diffuse hepatic fibrosis with regenerative nodules and altered liver architecture. D. Neurological deficit caused by interruption of cerebral blood flow due to arterial occlusion.