Which statement most accurately describes Sepsis?

A. A clinical spectrum caused by acute myocardial ischaemia, including unstable angina and myocardial infarction. B. Hyperglycaemia with ketonaemia and metabolic acidosis due to severe insulin deficiency. C. Life-threatening organ dysfunction caused by a dysregulated host response to infection. D. A macrocytic anaemia caused by impaired DNA synthesis, often from folate or vitamin B12 deficiency.