Which statement most accurately describes Systemic lupus erythematosus?

A. A clinical spectrum caused by acute myocardial ischaemia, including unstable angina and myocardial infarction. B. Persistent airflow limitation commonly related to smoking or noxious exposure. C. A microcytic anaemia caused by inadequate iron availability for haemoglobin synthesis. D. A multisystem autoimmune disease associated with diverse autoantibodies and organ involvement.