Pathology & Pharmacology MCQs

First-pass metabolism is presystemic metabolism that reduces oral bioavailability before a drug reaches systemic circulation.

Half-life is the time required for the plasma concentration of a drug to fall by one half.

Therapeutic index is a measure comparing toxic and effective doses and indicating a drug safety margin.

Warfarin is an oral anticoagulant that inhibits vitamin-K dependent clotting factor synthesis.

Insulin is a peptide hormone drug used to lower blood glucose and treat insulin deficiency.

Aminoglycoside is an antibiotic class associated with nephrotoxicity and ototoxicity.

Adverse drug reaction is a harmful and unintended response to a medicine used at normal doses.

Agonist is a ligand that binds to a receptor and activates it to produce a biological response.

Competitive antagonist is a reversible receptor blocker whose effect can be overcome by increasing agonist concentration.

Competitive antagonist is a reversible receptor blocker whose effect can be overcome by increasing agonist concentration.

First-pass metabolism is presystemic metabolism that reduces oral bioavailability before a drug reaches systemic circulation.

Half-life is the time required for the plasma concentration of a drug to fall by one half.