CPSP IMM Medicine MCQs

First-pass metabolism is presystemic metabolism that reduces oral bioavailability before a drug reaches systemic circulation.

Half-life is the time required for the plasma concentration of a drug to fall by one half.

Therapeutic index is a measure comparing toxic and effective doses and indicating a drug safety margin.

Warfarin is an oral anticoagulant that inhibits vitamin-K dependent clotting factor synthesis.

Insulin is a peptide hormone drug used to lower blood glucose and treat insulin deficiency.

Systemic lupus erythematosus is a multisystem autoimmune disease associated with diverse autoantibodies and organ involvement.

Pulmonary embolism is obstruction of pulmonary arteries, commonly by thrombus originating in deep veins.

Anaphylaxis is a rapid severe systemic hypersensitivity reaction that may compromise airway, breathing or circulation.

Agonist is a ligand that binds to a receptor and activates it to produce a biological response.

Competitive antagonist is a reversible receptor blocker whose effect can be overcome by increasing agonist concentration.

First-pass metabolism is presystemic metabolism that reduces oral bioavailability before a drug reaches systemic circulation.

Half-life is the time required for the plasma concentration of a drug to fall by one half.