Select the best definition of Systemic lupus erythematosus.

A. Persistent airflow limitation commonly related to smoking or noxious exposure. B. A syndrome in which the heart cannot meet metabolic demands or does so only at elevated filling pressures. C. A rapid severe systemic hypersensitivity reaction that may compromise airway, breathing or circulation. D. A multisystem autoimmune disease associated with diverse autoantibodies and organ involvement.