Which statement most accurately describes Hypothyroidism?

A. Diffuse hepatic fibrosis with regenerative nodules and altered liver architecture. B. Heavy proteinuria with hypoalbuminaemia, oedema and often hyperlipidaemia. C. A syndrome in which the heart cannot meet metabolic demands or does so only at elevated filling pressures. D. A state of deficient thyroid hormone action that may cause fatigue, weight gain and bradycardia.