Which statement most accurately describes Nephrotic syndrome?

A. Neurological deficit caused by interruption of cerebral blood flow due to arterial occlusion. B. A multisystem autoimmune disease associated with diverse autoantibodies and organ involvement. C. Diffuse hepatic fibrosis with regenerative nodules and altered liver architecture. D. Heavy proteinuria with hypoalbuminaemia, oedema and often hyperlipidaemia.