MCQ Collection
OPRA Pharmaceutical Sciences MCQs
Practice OPRA Pharmaceutical Sciences questions with answers and explanations.
Choose an option to check your answer.
A.
168.5
B.
59.3
C.
52.2
D.
99.5
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Correct Answer: B. 59.3
Explanation:
Use fraction remaining=e^(−kt).
Choose an option to check your answer.
A.
Both terms mean viral inactivation.
B.
Bacteriostatic agents always destroy spores.
C.
Bactericidal activity kills susceptible bacteria, whereas bacteriostatic activity inhibits growth.
D.
Bactericidal agents cannot have resistance.
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Correct Answer: C. Bactericidal activity kills susceptible bacteria, whereas bacteriostatic activity inhibits growth.
Explanation:
Bactericidal activity kills susceptible bacteria, whereas bacteriostatic activity inhibits growth.
Choose an option to check your answer.
A.
Phase I is limited to renal filtration.
B.
Phase I reactions commonly introduce or expose functional groups through oxidation, reduction or hydrolysis.
C.
Phase I reactions occur only outside the body.
D.
Phase I always produces an inactive metabolite.
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Correct Answer: B. Phase I reactions commonly introduce or expose functional groups through oxidation, reduction or hydrolysis.
Explanation:
Phase I reactions commonly introduce or expose functional groups through oxidation, reduction or hydrolysis.
Choose an option to check your answer.
A.
81.5
B.
122.6
C.
99.8
D.
20.4
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Correct Answer: A. 81.5
Explanation:
Use fraction remaining=e^(−kt).
Choose an option to check your answer.
A.
Blinding always increases sample size.
B.
A randomised controlled design reduces allocation bias and supports causal inference when well conducted.
C.
Randomisation guarantees zero measurement error.
D.
A case report proves population causality.
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Correct Answer: B. A randomised controlled design reduces allocation bias and supports causal inference when well conducted.
Explanation:
A randomised controlled design reduces allocation bias and supports causal inference when well conducted.
Choose an option to check your answer.
A.
It must be 100% when specificity is above 50%.
B.
Positive predictive value depends on disease prevalence as well as test performance.
C.
It is always equal to sensitivity.
D.
It is independent of prevalence.
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Correct Answer: B. Positive predictive value depends on disease prevalence as well as test performance.
Explanation:
Positive predictive value depends on disease prevalence as well as test performance.
Choose an option to check your answer.
A.
A depot formulation can prolong drug release and reduce dosing frequency.
B.
It prevents every adverse effect.
C.
It is identical to an intravenous bolus.
D.
It guarantees immediate peak concentration.
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Correct Answer: A. A depot formulation can prolong drug release and reduce dosing frequency.
Explanation:
A depot formulation can prolong drug release and reduce dosing frequency.
Choose an option to check your answer.
A.
12.98
B.
0.077
C.
33762
D.
14.98
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Correct Answer: A. 12.98
Explanation:
Concentration=amount/volume.
Choose an option to check your answer.
A.
18.86
B.
0.076
C.
646.8
D.
13.2
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Correct Answer: D. 13.2
Explanation:
Apply AUC=F×Dose/CL.
Choose an option to check your answer.
A.
50
B.
6.25
C.
12.5
D.
25
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Correct Answer: C. 12.5
Explanation:
After three half-lives, (1/2)^3=12.5%.
Choose an option to check your answer.
A.
A competitive antagonist usually shifts the agonist concentration–response curve to the right without reducing the maximal response.
B.
It removes the need for agonist binding.
C.
It irreversibly increases efficacy.
D.
It always raises the maximal response.
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Correct Answer: A. A competitive antagonist usually shifts the agonist concentration–response curve to the right without reducing the maximal response.
Explanation:
A competitive antagonist usually shifts the agonist concentration–response curve to the right without reducing the maximal response.
Choose an option to check your answer.
A.
It always decreases surface area.
B.
It eliminates first-pass metabolism.
C.
Reducing particle size can increase dissolution rate by increasing surface area.
D.
It guarantees chemical stability.
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Correct Answer: C. Reducing particle size can increase dissolution rate by increasing surface area.
Explanation:
Reducing particle size can increase dissolution rate by increasing surface area.
